ABC’s of Autism: M is for Mitochondria

M is for Mitochondrial Dysfunction. Mito-what you may be asking yourself. Take a moment and go back to high school biology class… remember that oval looking “organelle” in the cell with the squiggly lines- those little guys are your MITOCHONDRIA and they make energy to power every cell (except red blood cells) in your body! Just like little batteries. Take a look at these videos below to learn more.

Again I know you but be wondering what do mitochondria have to do with Autism.

To understand that you need to imagine a large city on a very hot day…when everyone is running their air conditioners and there is not enough energy to meet the demands of the body. A BROWN OUT… or a decrease in energy production until the demands (the air conditioners) lessen. So think about the same concept in the body and wonder for a moment what a brain running on half or quarter power might look like? Might it cause behavioral, psychiatric, aggressive, regressive or other types of behaviors that are often connected with a diagnosis of autism?

Turns out that is exactly what some researchers have found (here, here, here and here) when studying the biochemistry of autism and what is going on at a cellular level.

You can check out these Empowered Medical Advocacy resources if you want to dig deeper :

Mitochondrial Disease and Autism Webinar

MITOXIC Series

Mitochondrial Medical Home Presentation

Mito Resources

If you need more help navigting the Mitochondrial and Autism maze of diagnosis or treatment for your child, please contact us, we are happy to help.

1.)  Video- The Way Energy is Made

2.)  Mitochondrial Dysfunction and Autism Spectrum Disorders: A Simplified Approach  By Dr. Rossignol and Dr. Frye,  Autism Science Digest Issue 2

3.) Mitochondrial Disease Criteria:

Nijmegen Center for Mitochondrial Disorders scoring system (2001)

Morava criteria (2006)

Mitochondrial Medicine Society (2015)

Dr. Frye discussion of Modified Walker & Monrava criteria and examples: Autism File Magazine (June/July 2016) pg 30-31

4.) Alyssa Davi’s Articles: Part 1, Part 2

Dr. Martin Natowicz’s  When to see A Metabolic Geneticist? Red Flags 

5.) Journal Article (1998)- Autism: a mitochondrial disorder?

Journal Article (2005) – Mitochondrial dysfunction in autism spectrum disorders: a population-based study

6. Hannah Poling Articles: Court Documents

News Coverage- CBS, Time, NYTimes, Scientific American

7. Journal article (2006)- Developmental Regression and Mitochondrial Dysfunction in a Child With Autism

Journal article (2008)- Mitochondrial Disease in Autism Spectrum Disorder Patients: A Cohort Analysis

8. Dr. Richard Kelley’s manuscript (2009)

Journal Article (2010)- Fever plus mitochondrial disease could be risk factors for autistic regression.

Journal article (2010)-  Mitochondrial Dysfunction in Autism

9. Dr. Richard Frye’s research

10. Dr. Doug Wallace’s research

11. Dr. Bob Naviaux’s Research and parent perspectives  

and news coverage

Cell Danger Response journal article

12. MitoToxins Articles : Food coloring, Acetaminophen, Anesthesia, Aspartame

13. Top 10 Tests for Mito

14. Mitochondrial Medicine Society Tool Kit for Testing  

15. Dr. Fran Kendall’s article on Mitochondrial disease and Autism with Tier 1 and Tier 2 testing: here

16.  FAMILY SUPPORT:

Empowered Medical Advocacy Support Group (contact us for meeting info) and First Steps Membership group.

Facebook group- Mitochondrial Autism and Autism Like Mito

Mitoaction’s website and quarterly mito/autism support call: here

Mitoaction’s Mito Autism Roadmap

Bonus Links-

Cristy Balcells book: Living Well with Mitochondrial Disease

Cleveland Clinic CME on Autism Spectrum Disorders:
Research and Medical Treatment Implications, (to share with your doctor) : here